Objective: To investigate the efficacy of oral sweet solutions in relieving pain caused by vaccination in infants aged 1 to 12 months.
Methods: Related databases were searched to find related randomized control trails (RCTs). The quality of these RCTs was evaluated. The Meta analysis was performed using RevMan 5.3.
Results: A total of 20 RCTs involving 2 376 infants were included, and quality assessment showed that 6 RCTs had grade A quality and 14 had grade B quality. The Meta analysis showed that compared with sterile water, 25%-75% oral sweet solution significantly reduced crying time (WMD=-21.16, 95%CI -39.66 to -2.77, P<0.05) and the proportion of crying time (the duration of crying /3-minute periods after the injection) (WMD=-13.83, 95%CI -20.88 to -6.78, P<0.01), while the crying time showed no significant difference between the group treated with oral administration of 12% sucrose solution and non-intervention group. Co
Onclusions: Oral sweet solution (25%-75%; 2 mL) given 2 minutes before vaccination can effectively relieve the pain caused by vaccination in infants aged 1-12 months.
目的: 评价口服糖水对缓解1~12月婴儿预防接种所致疼痛的效果, 为临床实践提供依据。
方法: 通过计算机检索数据库, 纳入相关随机对照试验(RCTs)文献; 评价其研究质量、提取资料; 采用Revman 5.3软件行Meta分析。
结果: 共纳入20项RCTs(n=2 376), 有6项质量评价为A级, 14项为B级。Meta分析显示, 与无菌水相比, 口服25%~75%糖水降低了婴儿啼哭时间[WMD=-21.16, 95%CI(-39.66, -2.77), P < 0.05]、啼哭时间比例(啼哭时间/注射开始后3 min)[WMD=-13.83, 95%CI(-20.88, -6.78), P < 0.01];而口服12%蔗糖水组与无干预组相比, 婴儿啼哭持续时间无统计学差异。
结论: 预防接种前2 min, 口服25%~75%糖水2 mL可有效缓解1~12月婴儿预防接种所致疼痛。