Objective: To investigate the changes and clinical significance of biomarker fecal bile acids (BA) in children with Henoch-Schönlein purpura (HSP).
Methods: Nineteen children with HSP and twenty-seven healthy children were enrolled in this study. The stool samples were obtained at the acute and remission phases. Fecal BA levels were measured by high performance liquid chromatography mass spectrometry (HPLC-MS).
Results: The fecal cholic acid level in the HSP remission group was significantly higher than in the HSP acute group and the healthy control group (P<0.016). The fecal chenodeoxycholic acid level in the HSP remission group was significantly higher than in the healthy control group (P<0.016). The levels of fecal secondary colonic bile acids, deoxycholic acid and lithocholic acid, in the HSP acute and remission groups were significantly lower than in the healthy control group(P<0.05, P<0.016 respectively). No significant differences were found in the levels of fecal urosodeoxycholic acid among the three groups (P>0.05).
Conclusions: Fecal secondary colonic bile acids, deoxycholic acid and lithocholic acid, are in decrease in children with HSP at the acute stage, which may be involved in the pathogenesis and treatment outcomes of HSP.
目的: 探讨生物标记物粪便胆汁酸浓度在过敏性紫癜(HSP)患者中的变化及其在诊治中的临床意义。
方法: 选取2014~2016年确诊为HSP的19例患儿为HSP组, 另选取27例健康儿童为健康对照组。采集HSP组患儿急性期、恢复期及健康对照组儿童粪便标本, 应用液相质谱技术检测各组儿童粪便胆汁酸水平。
结果: HSP组患儿恢复期胆酸水平均高于健康对照组和HSP组急性期(P < 0.016)。HSP组患儿恢复期鹅脱氧胆酸水平高于健康对照组(P < 0.016)。HSP组患儿急性期和恢复期脱氧胆酸、石胆酸水平均低于健康对照组(分别P < 0.05、P < 0.016)。各组间熊去氧胆酸水平比较差异均无统计学意义(P>0.05)。
结论: HSP患儿急性期粪便次级胆汁酸脱氧胆酸和石胆酸低于健康对照组, 这可能与HSP的发病或转归有关。