Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Rahajeng N Tunjungputri; Marien I de Jonge; Astrid de Greeff; Saskia van Selm; Herma Buys; Jose F Harders-Westerveen; Norbert Stockhofe-Zurwieden; Rolf T Urbanus; Phillip G de Groot; Hilde E Smith; Andre J van der Ven; Quirijn de Mast

doi:10.1016/j.thromres.2016.06.016

Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Thromb Res. 2016 Aug:144:123-6. doi: 10.1016/j.thromres.2016.06.016. Epub 2016 Jun 16.

Affiliations

¹ Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Center for Tropical and Infectious Diseases (CENTRID), Diponegoro University-Dr. Kariadi Hospital, Semarang, Indonesia. Electronic address: Rahajeng.Tunjungputri@radboudumc.nl.
² Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
³ Central Veterinary Institute, Part of Wageningen UR, Lelystad, The Netherlands.
⁴ Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands.
⁵ Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Clinical Chemistry and Haematology, University Medical Centre, Utrecht, The Netherlands.
⁶ Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

PMID: 27322088
DOI: 10.1016/j.thromres.2016.06.016

Abstract

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

Keywords: Infection; Myocardial infarction; Platelet activation; Platelets; Pneumonia; Streptococcus pneumoniae.

Publication types

Letter

MeSH terms

Animals
Blood Platelets / microbiology*
Blood Platelets / pathology
Disease Models, Animal
Humans
Platelet Activation*
Pneumococcal Infections / blood*
Pneumococcal Infections / complications*
Pneumococcal Infections / pathology
Pneumonia, Pneumococcal / blood
Pneumonia, Pneumococcal / complications
Pneumonia, Pneumococcal / pathology
Streptococcus pneumoniae / isolation & purification
Streptococcus pneumoniae / physiology*
Swine