Poly(ADP-ribose): From chemical synthesis to drug design

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3395-403. doi: 10.1016/j.bmcl.2016.06.008. Epub 2016 Jun 6.

Abstract

Poly(ADP-ribose) (PAR) is an important biopolymer, which is involved in various life processes such as DNA repair and replication, modulation of chromatin structure, transcription, cell differentiation, and in pathogenesis of various diseases such as cancer, diabetes, ischemia and inflammations. PAR is the most electronegative biopolymer and this property is essential for its binding with a wide range of proteins. Understanding of PAR functions in cell on molecular level requires chemical synthesis of regular PAR oligomers. Recently developed methodologies for chemical synthesis of PAR oligomers, will facilitate the study of various cellular processes, involving PAR.

Keywords: Biosynthesis; Cell functions; Chemical synthesis; Poly(ADP-ribose); Structure and properties.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dose-Response Relationship, Drug
  • Drug Design*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Humans
  • Molecular Structure
  • Poly Adenosine Diphosphate Ribose / chemical synthesis
  • Poly Adenosine Diphosphate Ribose / chemistry
  • Poly Adenosine Diphosphate Ribose / pharmacology*
  • Poly(ADP-ribose) Polymerases / metabolism*
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Poly Adenosine Diphosphate Ribose
  • Poly(ADP-ribose) Polymerases