Pyrofomins A-D, polyoxygenated sesquiterpenoids from Pyrofomes demidoffii

Dang Ngoc Quang; Christoph Wagner; Kurt Merzweiler; Dawit Abate; Andrea Porzel; Jürgen Schmidt; Norbert Arnold

doi:10.1016/j.fitote.2016.06.004

Pyrofomins A-D, polyoxygenated sesquiterpenoids from Pyrofomes demidoffii

Fitoterapia. 2016 Jul:112:229-32. doi: 10.1016/j.fitote.2016.06.004. Epub 2016 Jun 14.

Authors

Dang Ngoc Quang¹, Christoph Wagner², Kurt Merzweiler², Dawit Abate³, Andrea Porzel⁴, Jürgen Schmidt⁴, Norbert Arnold⁵

Affiliations

¹ Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany; Faculty of Chemistry, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay, Hanoi, Vietnam.
² Martin Luther University Halle-Wittenberg, Institute of Chemistry, Kurt-Mothes-Str. 2, 06120 Halle (Saale), Germany.
³ Department of Microbial, Cellular and Molecular Biology, College of Natural Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
⁴ Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany.
⁵ Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany. Electronic address: narnold@ipb-halle.de.

PMID: 27316978
DOI: 10.1016/j.fitote.2016.06.004

Abstract

Pyrofomins A-D, four polyoxygenated sesquiterpenoids have been isolated from the methanolic extract of the fruit bodies of Pyrofomes demidoffii. Their structures are elucidated by IR, HR-FTICR-MS, and 2D NMR spectroscopy. Furthermore, the cedrane carbon skeleton of pyrofomin A (1) is confirmed by X-ray crystallographic analysis. The sesquiterpenoids 1-4 show neither cytotoxicity against KB cells nor antimicrobial activity.

Keywords: Pyrofomes demidoffii; Pyrofomin; Sesquiterpenoid.

MeSH terms

Cell Line, Tumor
Fruiting Bodies, Fungal / chemistry
Humans
Microbial Sensitivity Tests
Molecular Structure
Polyporaceae / chemistry*
Sesquiterpenes / chemistry*
Sesquiterpenes / isolation & purification

Substances

Sesquiterpenes
pyrofomin A