Spatiotemporal plasticity of miRNAs functions: The miR-17-92 case

Tiziana Bonaldi; Marija Mihailovich

doi:10.1080/23723556.2016.1156216

Spatiotemporal plasticity of miRNAs functions: The miR-17-92 case

Mol Cell Oncol. 2016 Apr 15;3(3):e1156216. doi: 10.1080/23723556.2016.1156216. eCollection 2016 May.

Authors

Tiziana Bonaldi¹, Marija Mihailovich¹

Affiliation

¹ Department of Experimental Oncology, European Institute of Oncology , Milan, Italy.

Abstract

The functional effect of a specific miRNA is tightly linked to the transcriptome, thus having the potential to elicit distinct outcomes in different cellular states. Our recent discovery of a dual role of the miR-17-92 cluster, which shifts from oncogene to tumor suppressor during lymphoma progression, exemplifies the spatiotemporal plasticity of miRNAs.

Keywords: 3´-UTR shortening; Alternative polyadenylation (APA); miR-17-92; miRNA.