Outbreak of H7N8 Low Pathogenic Avian Influenza in Commercial Turkeys with Spontaneous Mutation to Highly Pathogenic Avian Influenza

Mary Lea Killian; Mia Kim-Torchetti; Nichole Hines; Sam Yingst; Thomas DeLiberto; Dong-Hun Lee

doi:10.1128/genomeA.00457-16

Outbreak of H7N8 Low Pathogenic Avian Influenza in Commercial Turkeys with Spontaneous Mutation to Highly Pathogenic Avian Influenza

Genome Announc. 2016 Jun 16;4(3):e00457-16. doi: 10.1128/genomeA.00457-16.

Authors

Mary Lea Killian¹, Mia Kim-Torchetti², Nichole Hines¹, Sam Yingst³, Thomas DeLiberto⁴, Dong-Hun Lee⁵

Affiliations

¹ National Veterinary Services Laboratories, Veterinary Services, U.S. Department of Agriculture (USDA), Ames, Iowa, USA.
² National Veterinary Services Laboratories, Veterinary Services, U.S. Department of Agriculture (USDA), Ames, Iowa, USA mia.kim.torchetti@aphis.usda.gov.
³ Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, Indiana, USA.
⁴ USDA Wildlife Services National Wildlife Research Center, Fort Collins, Colorado, USA.
⁵ USDA Agriculture Research Service, Southeast Poultry Research Laboratory, Athens, Georgia, USA.

Abstract

Highly pathogenic avian influenza (HPAI) subtype H7N8 was detected in commercial turkeys in January 2016. Control zone surveillance discovered a progenitor low pathogenic avian influenza (LPAI) virus in surrounding turkey flocks. Data analysis supports a single LPAI virus introduction followed by spontaneous mutation to HPAI on a single premises.