Advances in the synthesis of α-quaternary α-ethynyl α-amino acids

Amino Acids. 2016 Sep;48(9):2081-101. doi: 10.1007/s00726-016-2276-2. Epub 2016 Jun 16.

Abstract

α-Quaternary α-ethynyl α-amino acids are an important class of non-proteinogenic amino acids that play an important role in the development of peptides and peptidomimetics as therapeutic agents and in the inhibition of enzyme activities. This review provides an overview of the literature concerning synthesis and applications of α-quaternary α-ethynyl α-amino acids covering the period from 1977 to 2015.

Keywords: Quaternary amino acid; Unsaturated amino acid; α-Quaternary α-ethynyl α-amino acids.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry*
  • Peptides / chemical synthesis*
  • Peptides / chemistry*

Substances

  • Amino Acids
  • Peptides