Hypocapnia and hyperoxia induction using a hyperventilation protocol in electroconvulsive therapy
Rev Psiquiatr Salud Ment. 2017 Jan-Mar;10(1):21-27.
doi: 10.1016/j.rpsm.2016.04.002.
Epub 2016 Jun 13.
[Article in
English,
Spanish]
Affiliations
- 1 Grupo de Neurociencias del Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Unidad Clínica y de Investigación de Trastornos Afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-Institut Català de la Salut (ICS), L'Hospitalet de Llobregat, Barcelona, España.
- 2 Servicio de Anestesiología y Reanimación, Hospital Universitari de Bellvitge-Institut Català de la Salut (ICS), L'Hospitalet de Llobregat, Barcelona, España.
- 3 Grupo de Neurociencias del Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Unidad Clínica y de Investigación de Trastornos Afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-Institut Català de la Salut (ICS), L'Hospitalet de Llobregat, Barcelona, España; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) G17, Universitat de Barcelona (UB), Barcelona, España.
- 4 Grupo de Neurociencias del Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Unidad Clínica y de Investigación de Trastornos Afectivos, Servicio de Psiquiatría, Hospital Universitari de Bellvitge-Institut Català de la Salut (ICS), L'Hospitalet de Llobregat, Barcelona, España; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) G17, Universitat de Barcelona (UB), Barcelona, España. Electronic address: murretavizcaya@bellvitgehospital.cat.
Abstract
Introduction:
Hyperventilation in electroconvulsive therapy sessions has been associated with seizure threshold, seizure characteristics, and cognitive effects. There is no consensus on the optimal procedure of applying hyperventilation manoeuvres during electroconvulsive therapy.
Material and methods:
Prospective evaluation of the effects of systematic use of hyperventilation manoeuvres with facial mask and capnography (protocolized hyperventilation [pHV]), on ventilation parameters and on seizures. The study included a sample of 130 sessions (65 performed according to hyperventilation standard practice and 65 successive sessions, with pHV) of 35 patients over a period of 10 weeks.
Results:
The pHV manoeuvres reduced exhaled CO2 and increased O2 saturation significantly (P<.001). The average CO2 reduction achieved was 6.52±4.75mmHg (95% CI -7.7 to -5.3). The CO2 values after pHV correlated significantly with seizure duration and O2 values, with other electroencephalographic quality indices. In pHV sessions, compared with sessions performed according to hyperventilation standard practice, the average lengthening of the motor and electroencephalographic seizure was 3.86±14.62 and 4.73±13.95s, respectively. No differences were identified in other ictal quality parameters.
Conclusions:
The proposed pHV manoeuvres significantly modify ventilation parameters. The hypocapnia and hyperoxia obtained by applying these manoeuvres lengthen the duration of seizures without worsening the quality of the electroencephalographic trace. The use of pHV is generalisable and might improve electroconvulsive therapy procedure without adding costs.
Keywords:
Capnografía; Capnography; Convulsiones; Electroconvulsive therapy; Hiperventilación; Hipocapnia; Hyperventilation; Hypocapnia; Seizures; Terapia electroconvulsiva.
Copyright © 2016 SEP y SEPB. Publicado por Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Capnography
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Electroconvulsive Therapy / methods*
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Female
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Humans
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Hyperoxia* / diagnosis
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Hyperoxia* / etiology
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Hyperventilation* / diagnosis
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Hyperventilation* / etiology
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Hypocapnia* / diagnosis
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Hypocapnia* / etiology
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Male
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Middle Aged
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Outcome Assessment, Health Care
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Prospective Studies
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Respiration, Artificial / methods*