In Silico Models for Acute Systemic Toxicity

Julien Burton; Andrew P Worth; Ivanka Tsakovska; Antonia Diukendjieva

doi:10.1007/978-1-4939-3609-0_10

In Silico Models for Acute Systemic Toxicity

Methods Mol Biol. 2016:1425:177-200. doi: 10.1007/978-1-4939-3609-0_10.

Authors

Julien Burton¹, Andrew P Worth², Ivanka Tsakovska³, Antonia Diukendjieva³

Affiliations

¹ Systems Toxicology Unit and EURL ECVAM, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, Varese, Italy.
² Systems Toxicology Unit and EURL ECVAM, Institute for Health and Consumer Protection, Joint Research Centre, European Commission, Ispra, Varese, Italy. Andrew.WORTH@ec.europa.eu.
³ Department of QSAR & Molecular Modeling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Sofia, Bulgaria.

PMID: 27311468
DOI: 10.1007/978-1-4939-3609-0_10

Abstract

In this chapter, we give an overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review the availability of structure-based computational models that are available and potentially useful in the assessment of acute systemic toxicity. The most recently published literature models for acute systemic toxicity are also discussed, and perspectives for future developments in this field are offered.

Keywords: Acute systemic toxicity; In silico model; Organ-specific toxicity; Regulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animal Testing Alternatives / legislation & jurisprudence*
Animal Testing Alternatives / methods
Animals
Computer Simulation
European Union
Humans
Quantitative Structure-Activity Relationship
Toxicity Tests, Acute / methods*