Abstract
The chemical investigation on the fruiting bodies of Amauroderma subresinosum led to the isolation of 10 compounds including 2 new ones named amaurosubresin (1) and erythro(23,24)-5α,6α-epoxyergosta-8-ene-7-one-3β,23-diol (2). Their structures were elucidated on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) of two new isolates exhibited definite inhibitory activity.
Keywords:
AChE inhibitory activity; Amauroderma subresinosum; Ganodermataceae; amaurosubresin; ergosta.
MeSH terms
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Acetylcholinesterase / drug effects*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology
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Ergosterol / analogs & derivatives*
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Ergosterol / chemistry
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Ergosterol / isolation & purification
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Ergosterol / pharmacology
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Fruiting Bodies, Fungal / chemistry
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Hydroquinones / chemistry
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Hydroquinones / isolation & purification*
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Hydroquinones / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Polyporales / chemistry*
Substances
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Cholinesterase Inhibitors
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Hydroquinones
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amaurosubresin
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erythro(23,24)-5alpha,6alpha-epoxyergosta-8-ene-7-one-3beta,23-diol
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Acetylcholinesterase
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Ergosterol