p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis

Xiaofeng Cai-McRae; Vassiliki Karantza

doi:10.4161/23723556.2014.975035

p62: a hub of multiple signaling pathways in HER2-induced mammary tumorigenesis

Mol Cell Oncol. 2015 Mar 17;2(3):e975035. doi: 10.4161/23723556.2014.975035. eCollection 2015 Jul-Sep.

Authors

Xiaofeng Cai-McRae¹, Vassiliki Karantza²

Affiliations

¹ Rutgers University; The State University of New Jersey; New Brunswick, NJ USA; Rutgers Cancer Institute of New Jersey; 195 Little Albany Street; New Brunswick, NJ USA.
² Rutgers University; The State University of New Jersey; New Brunswick, NJ USA; Rutgers Cancer Institute of New Jersey; 195 Little Albany Street; New Brunswick, NJ USA; Division of Medical Oncology; Department of Internal Medicine; Rutgers Robert Wood Johnson Medical School; Piscataway, NJ USA.

Abstract

We recently reported that depletion of p62 in the background of human epidermal growth factor receptor 2 (HER2) overexpression sensitizes mammary tumor cells to amino acid deprivation, abolishes cellular transformation in vitro, and suppresses mammary tumorigenesis in vivo. Extensive investigation on the underlying molecular mechanisms has revealed a multifaceted role for p62 in HER2-associated mammary tumorigenesis.

Keywords: AKT; HER2; NRF2; PTEN; SQSTM1; breast cancer.