PRKD2: A two-pronged kinase crucial for the tumor-supporting activity of HSP90

Ninel Azoitei; Stefan Fröhling; Claudia Scholl; Thomas Seufferlein

doi:10.4161/23723556.2014.981444

PRKD2: A two-pronged kinase crucial for the tumor-supporting activity of HSP90

Mol Cell Oncol. 2015 Jan 7;2(2):e981444. doi: 10.4161/23723556.2014.981444. eCollection 2015 Apr-Jun.

Authors

Ninel Azoitei¹, Stefan Fröhling², Claudia Scholl², Thomas Seufferlein¹

Affiliations

¹ Center for Internal Medicine I; Ulm University Hospital ; Ulm, Germany.
² Department of Translational Oncology; National Center for Tumor Diseases and German Cancer Research Center ; Heidelberg, Germany.

Abstract

PRKD2 plays an important role in tumor cell survival, proliferation, migration, and angiogenesis. We recently reported that cell death and impaired blood vessel formation evoked by inhibition of the HSP90 chaperone in human cancer cells of various tissue origins is mediated by destabilization of PRKD2.

Keywords: Protein kinase D2; heat shock protein 90 (HSP90) chaperone; hypoxia; nuclear factor kappa B (NF-kB); tumor angiogenesis.