Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells "it's time to die"

Benedetto Grimaldi

doi:10.4161/23723548.2014.965626

Lysosomotropic REV-ERB antagonism: A metabolic connection between circadian rhythm and autophagy may tell cancer cells "it's time to die"

Mol Cell Oncol. 2014 Oct 30;2(2):e965626. doi: 10.4161/23723548.2014.965626. eCollection 2015 Apr-Jun.

Author

Benedetto Grimaldi¹

Affiliation

¹ Istituto Italiano di Tecnologia; Department of Drug Discovery and Development ; Genova, Italy.

Abstract

The discovery that inhibition of a circadian regulator enhances autophagy-dependent cancer cell death reveals potential avenues for the development of new multifunctional anticancer agents. Further studies may elucidate novel crosstalk between circadian rhythm, metabolism, and autophagy that determines cancer cell viability.

Keywords: REV-ERB; anticancer agents; autophagy; cancer metabolism; chronotherapy; circadian clock; dual inhibitor; nuclear receptors.