The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks

Andreas Kakarougkas; Jessica A Downs; Penny A Jeggo

doi:10.4161/23723548.2014.970072

The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks

Mol Cell Oncol. 2015 Jan 23;2(1):e970072. doi: 10.4161/23723548.2014.970072. eCollection 2015 Jan-Mar.

Authors

Andreas Kakarougkas¹, Jessica A Downs², Penny A Jeggo²

Affiliations

¹ Department of Biology; School of Sciences and Engineering; The American University in Cairo ; Cairo, Egypt.
² Genome Damage and Stability Center; Life Sciences; University of Sussex ; Brighton, UK.

Abstract

Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation.(1) We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remodeling complex and the polycomb repressive complex (PRC1/2) are also required.(2) Failure to activate transcriptional suppression impedes a rapid DSB repair process.