Thermographic Abnormalities are Associated with Future Digital Ulcers and Death in Patients with Systemic Sclerosis

J Rheumatol. 2016 Aug;43(8):1519-22. doi: 10.3899/jrheum.151412. Epub 2016 Jun 15.

Abstract

Objective: Capillaroscopic abnormalities are predictive of future digital ulcers (DU). Our aim was to investigate whether functional digital vascular disease (thermographically assessed) is also associated with future DU.

Methods: A retrospective case note review of patients with systemic sclerosis (SSc) undergoing thermography and who were followed for up to about 3 years.

Results: There were 138 patients (equal mixture of normal/abnormal thermography). Patients with abnormal thermography were more likely to develop DU (clinician-observed and/or patient-reported, OR 2.84, p = 0.021), including multiple episodes, and more likely to die (OR 5.42, p = 0.050).

Conclusion: Abnormal thermography is associated with DU and disease severity in patients with SSc.

Keywords: DEATH; DIGITAL ULCERS; SCLERODERMA; SYSTEMIC SCLEROSIS; THERMOGRAPHY.

MeSH terms

  • Adult
  • Aged
  • Female
  • Fingers / blood supply*
  • Fingers / diagnostic imaging
  • Humans
  • Male
  • Microscopic Angioscopy*
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Scleroderma, Systemic / diagnostic imaging*
  • Scleroderma, Systemic / physiopathology
  • Skin Ulcer / diagnostic imaging*
  • Skin Ulcer / physiopathology
  • Thermography*
  • Vascular Diseases / diagnostic imaging*
  • Vascular Diseases / physiopathology