Abstract
A 60-year-old man was diagnosed with adenocarcinoma of the esophagogastric junction with lymph node metastasis along the left gastric artery. The clinical stage was determined to be T4b, N1, M0, Stage IIIB, and a neoadjuvant chemotherapy (NAC)regimen of capecitabine/CDDP plus trastuzumab was selected for treatment. Before 3 courses of chemotherapy, the patient developed perforated gastric cancer. With conservative therapy, we were able to obtain closure of the perforation without affecting the curability of the cancer. We changed the chemotherapy regimen to S-1/CDDP plus trastuzumab, and the patient underwent curative resection.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Cisplatin / administration & dosage
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Drug Combinations
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Esophagogastric Junction / pathology*
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Humans
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Male
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Neoadjuvant Therapy*
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Oxonic Acid / administration & dosage
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Receptor, ErbB-2 / analysis
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Stomach Diseases / etiology
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Stomach Diseases / surgery*
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Stomach Neoplasms / complications
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / pathology
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Stomach Neoplasms / surgery
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Tegafur / administration & dosage
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Trastuzumab / administration & dosage
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Treatment Outcome
Substances
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Drug Combinations
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S 1 (combination)
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Tegafur
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Oxonic Acid
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ERBB2 protein, human
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Receptor, ErbB-2
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Trastuzumab
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Cisplatin