A New Role for Glia in Leptin Action and Energy Balance

Warren Pan; Martin G Myers Jr

doi:10.1016/j.cmet.2016.05.020

A New Role for Glia in Leptin Action and Energy Balance

Cell Metab. 2016 Jun 14;23(6):969-970. doi: 10.1016/j.cmet.2016.05.020.

Authors

Warren Pan¹, Martin G Myers Jr²

Affiliations

¹ Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA.
² Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA. Electronic address: mgmyers@umich.edu.

PMID: 27304498
DOI: 10.1016/j.cmet.2016.05.020

Abstract

Chemo- or radiotherapy against dividing cells in the brain can promote obesity. Djogo et al. (2016) suggest that the loss of NG2 glia and diminished leptin action in the median eminence underlie this response, likely due to the loss of dendrites originating in the adjacent arcuate nucleus.

Publication types

Comment

MeSH terms

Animals
Energy Metabolism*
Humans
Leptin / metabolism*
Mice
Models, Biological
Neuroglia / metabolism*

Substances

Leptin

Grants and funding

T32 GM007315/GM/NIGMS NIH HHS/United States