One-pot three-component synthesis of quinazolines via a copper-catalysed oxidative amination reaction

Tiantian Duan; Tianran Zhai; Huanhuan Liu; Zilong Yan; Yue Zhao; Lei Feng; Chen Ma

doi:10.1039/c6ob00625f

One-pot three-component synthesis of quinazolines via a copper-catalysed oxidative amination reaction

Org Biomol Chem. 2016 Jul 6;14(27):6561-7. doi: 10.1039/c6ob00625f.

Authors

Tiantian Duan¹, Tianran Zhai¹, Huanhuan Liu¹, Zilong Yan¹, Yue Zhao¹, Lei Feng¹, Chen Ma²

Affiliations

¹ Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China.
² Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China and State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China. chenma@sdu.edu.cn.

PMID: 27304252
DOI: 10.1039/c6ob00625f

Abstract

A copper-catalysed three-component reaction for constructing a series of quinazoline derivatives has been developed. In this system, solvents act as the reactants and different functional groups are well tolerated to obtain corresponding products in moderate to good yields.