We investigated commuter exposure to volatile organic compounds in the metropolitan area of Mexico City in 2011 in private car, microbus, bus, metro, metrobus, and trolley bus. A similar survey was conducted in 2002 before initiation of the ProAire2002-2010 program aimed at reducing air pollution. Formaldehyde, acetaldehyde, benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene were sampled while traveling during the morning rush hour in May 2011. Compared with the 2002 survey, in-vehicle concentrations were substantially lower in 2011, except for formaldehyde in microbuses (35% higher than in 2002). The reductions were 17-42% (except microbuses), 25-44%, 41-61%, 43-61%, 71-79%, 80-91%, and 79-93% for formaldehyde, acetaldehyde, benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene, respectively. These reductions are considered to be the outcome of some of the actions in the ProAire2002-2010 program. In some microbuses, use of liquid petroleum gas may have increased in-vehicle formaldehyde concentrations. The reduction in predicted excess cancer incidence of commuters because of ProAire2002-2010 was estimated to be 1.4 cases/yr. In addition, if every microbus commuter changed their transport mode to bus, metro, or metrobus in the future, the estimated excess cancer incidence of commuters could be further decreased from 6.4 to 0.88-2.2 cases/year.