Abstract
Phytochemical investigation of the bark of Guatteria friesiana afforded 12 new aporphines (1-12), along with nine known alkaloids (13-21). The structures of the new alkaloids were determined on the basis of spectroscopic data interpretation. The cytotoxic activity of the isolated compounds against a small panel of tumor cell lines was assessed using the Alamar blue assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Aporphines / chemistry
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Aporphines / isolation & purification*
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Aporphines / pharmacology
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Brazil
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Drug Screening Assays, Antitumor
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Guatteria / chemistry*
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HL-60 Cells
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Hep G2 Cells
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Humans
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Mice
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry*
Substances
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7,7-dimethylaporphine
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Aporphines