Syntheses of (14β,17α)-14-Hydroxy- and (14β,17α)-2,14-Dihydroxyestradiols and Their Activities

M Sakakibara; A Ogawa Uchida

doi:10.1271/bbb.60.411

Syntheses of (14β,17α)-14-Hydroxy- and (14β,17α)-2,14-Dihydroxyestradiols and Their Activities

Biosci Biotechnol Biochem. 1996 Jan;60(3):411-4. doi: 10.1271/bbb.60.411.

Authors

M Sakakibara¹, A Ogawa Uchida¹

Affiliation

¹ a Pharmaceutical Research Laboratories , Kirin Brewery Co., Ltd , 3 Miyahara-cho, Takasaki, Gunma 370-12 , Japan.

PMID: 27299546
DOI: 10.1271/bbb.60.411

Abstract

Structure 1 is proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and (14β,17α)-14-hydroxy- and (14β, 17α)-2,14-dihydroxyestradiols (2 and 3) were synthesized as models for studies on 1. The latter compound was remarkably potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.

Keywords: 14β-hydroxyestrogens; cardiotonic; endogenous digitalis-like factor; hypertension; vasocontraction.