Abstract
Two new coumarins, named (±)-euryacoumarin A (1) and 6-demethylobtusinin (2), and one new natural coumarin, named euryacoumarin B (3), along with two known compounds, scopoletin (4) and obtusinol (5), were isolated from the stems of Eurya chinensis. Their structures were elucidated by means of extensive spectroscopic methods and comparison with data reported in the literatures. Compound 1 exhibited significant inhibition of LPS-induced nitric oxide (NO) production in RAW264.7 cells with IC50 value of 35.64 ± 1.73 μM, and showed marginal antibacterial activities against Bacillus subtilis and B. cereus with MIC values of 50.59 ± 2.12 and 35.42 ± 0.96 μM, respectively.
Keywords:
Eurya chinensis; Theaceae; anti-inflammatory; antibacterial; coumarin.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology*
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology*
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Magnoliopsida / chemistry*
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Molecular Structure
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Nitric Oxide / biosynthesis
Substances
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6-demethylobtusinin
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Anti-Bacterial Agents
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Anti-Infective Agents
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Anti-Inflammatory Agents
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Coumarins
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Lipopolysaccharides
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euryacoumarin A
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euryacoumarin B
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Nitric Oxide