Omentin-1 and risk of myocardial infarction and stroke: Results from the EPIC-Potsdam cohort study

Atherosclerosis. 2016 Aug:251:415-421. doi: 10.1016/j.atherosclerosis.2016.06.003. Epub 2016 Jun 2.

Abstract

Background and aims: The recently identified adipokine omentin-1 is inversely associated with body fatness, metabolic syndrome and cardiovascular disease (CVD) in cross-sectional analyses. However, prospective data on the association between plasma omentin-1 levels and future risk of CVD are lacking. The aim of the study was to investigate the relationship between omentin-1 and incident myocardial infarction (MI) and stroke.

Methods: We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising a subsample of 2084 participants, including 50 CVD cases and 350 external incident CVD cases (mean follow-up of 8.2 ± 1.6 years). Prentice modified Cox regression adjusted for established CVD risk factors was used to estimate associations between omentin-1 and risk of MI and stroke, interactions were tested with cross-product terms.

Results: After multivariable adjustment, omentin-1 was not significantly associated with risk of MI (HR per doubling omentin-1:1.17; 95%-CI:0.79-1.72; p = 0.43), but with higher risk of stroke (HR per doubling omentin-1:2.22; 95%-CI:1.52-3.22; p < 0.0001). In subgroup analyses, associations between omentin-1 and stroke risk were generally stronger in lower versus higher CVD risk groups. For example, risk of stroke was stronger in participants without metabolic syndrome (HR per doubling omentin-1:2.58; 95%-CI:1.64-4.07; p < 0.0001) compared to those with metabolic syndrome (HR per doubling omentin-1:1.21; 95%-CI:0.59-2.50; p = 0.60) (p for interaction = 0.05). Similar interactions were observed when participants were classified in low or high risk groups according to waist circumference, triglyceride, hsCRP or adiponectin levels.

Conclusions: Omentin-1 concentrations may be related to increased stroke risk. This association is stronger in metabolically healthy individuals.

Keywords: Adipokines; Adiponectin; Intelectin-1; Risk factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipokines / blood
  • Adipokines / physiology
  • Adiponectin / metabolism
  • C-Reactive Protein / metabolism
  • Cohort Studies
  • Cytokines / blood*
  • Cytokines / physiology
  • Female
  • GPI-Linked Proteins / blood
  • GPI-Linked Proteins / physiology
  • Humans
  • Lectins / blood*
  • Lectins / physiology
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Infarction / blood*
  • Myocardial Infarction / diagnosis
  • Risk Factors
  • Stroke / blood*
  • Stroke / diagnosis
  • Triglycerides / blood
  • Waist Circumference

Substances

  • ADIPOQ protein, human
  • Adipokines
  • Adiponectin
  • Cytokines
  • GPI-Linked Proteins
  • ITLN1 protein, human
  • Lectins
  • Triglycerides
  • C-Reactive Protein