We created a 2013 combination antibiogram of healthcare-associated urinary tract infection. The 2013 antibiogram-determined regimen was evaluated in a 2014 cohort who had received empirical therapy. The regimen was statistically more likely to represent adequate treatment than actual prescriptions. A customized antibiogram may guide empirical therapy for specific patients. Infect Control Hosp Epidemiol 2016;37:1101-1104.