Data on clinical significance of GAS2 in colorectal cancer cells

Chun-Chao Chang; Chi-Cheng Huang; Shung-Haur Yang; Chih-Cheng Chien; Chia-Long Lee; Chi-Jung Huang

doi:10.1016/j.dib.2016.05.010

Data on clinical significance of GAS2 in colorectal cancer cells

Data Brief. 2016 May 11:8:82-6. doi: 10.1016/j.dib.2016.05.010. eCollection 2016 Sep.

Authors

Chun-Chao Chang¹, Chi-Cheng Huang², Shung-Haur Yang³, Chih-Cheng Chien⁴, Chia-Long Lee⁵, Chi-Jung Huang⁶

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
² School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; Breast Center, Cathay General Hospital, Taipei, Taiwan; School of Medicine, Taipei Medical University, Taipei, Taiwan.
³ Department of Surgery, Taipei-Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang Ming University, Taipei, Taiwan.
⁴ School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; Department of Anesthesiology, Cathay General Hospital, Taipei, Taiwan.
⁵ School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan; Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan.
⁶ Department of Medical Research, Cathay General Hospital, Taipei, Taiwan; Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.

Abstract

The growth arrest-specific 2 (GAS2) was cloned and found to be upregulated in the feces of recurrent CRC patients. This overexpressed GAS2 induced different patterns of gene expressions in CRC cells. Briefly, one cell proliferation marker, Ki-67 antigen (Ki-67), was upregulated in the cells with overexpressed GAS2, "Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer" [1]. Whereas, the expression of another cell proliferation marker, proliferating cell nuclear antigen (PCNA), changed insignificantly [1]. In addition, the mRNA level of one cyclin involving in both cell cycle G1/S and G2/M transitions was also not affected by GAS2 overexpression, "Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A" [2]. The experimental design and procedures in this article can be helpful for understanding the molecular significance of GAS2 in SW480 and SW620 CRC cells.