Background: Clinical studies have obtained inconsistent results of statin use on cancer outcomes. This study investigated the association between statin use and lung cancer mortality.
Results: The use of statin decreased mortality (hazard ratio = 0.91; 95% confidence interval: 0.86-0.96; P < .01). The patients with a high cumulative defined daily dose of statin use before lung cancer diagnosis exhibited a low risk of mortality.
Materials and methods: We conducted a population-based case-control study of patients with dyslipidemia. Among them, 6270 had used statins for at least 3 months before lung cancer diagnosis, and 6270 had never used statins.
Conclusions: We found that statin use can reduce lung cancer mortality. A further prospective study is necessary to confirm these findings.
Keywords: lung cancer; population-based case-control study; statin.