Cleavage of the C(O)-S Bond of Thioesters by Palladium/Norbornene/Copper Cooperative Catalysis: An Efficient Synthesis of 2-(Arylthio)aryl Ketones

Fenggang Sun; Miao Li; Congfa He; Bin Wang; Bin Li; Xianwei Sui; Zhenhua Gu

doi:10.1021/jacs.6b02495

Cleavage of the C(O)-S Bond of Thioesters by Palladium/Norbornene/Copper Cooperative Catalysis: An Efficient Synthesis of 2-(Arylthio)aryl Ketones

J Am Chem Soc. 2016 Jun 22;138(24):7456-9. doi: 10.1021/jacs.6b02495. Epub 2016 Jun 13.

Authors

Fenggang Sun¹, Miao Li¹, Congfa He¹, Bin Wang¹, Bin Li¹, Xianwei Sui¹, Zhenhua Gu¹

Affiliation

¹ Department of Chemistry, University of Science and Technology of China , 96 Jinzhai Road, Hefei, Anhui 230026, China.

PMID: 27280716
DOI: 10.1021/jacs.6b02495

Abstract

A Pd/norbornene/Cu cooperative catalysis for the efficient synthesis of 2-(arylthio)aryl ketones from aryl halides and thioesters has been developed. The first example of cooperative catalysis by palladium, norbornene, and copper, wherein the C(O)-S bond of thioesters is cleaved by a Pd(II) palladacycle with the assistance of CuI, has been observed.

Publication types

Research Support, Non-U.S. Gov't