Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

Lunjie Lu; Jun Zhou; Jingying Zhang; Jun Che; Yang Jiao; Yusong Zhang

doi:10.1155/2016/4097398

Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model

Evid Based Complement Alternat Med. 2016:2016:4097398. doi: 10.1155/2016/4097398. Epub 2016 May 4.

Authors

Lunjie Lu¹, Jun Zhou², Jingying Zhang³, Jun Che⁴, Yang Jiao³, Yusong Zhang⁵

Affiliations

¹ Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Department of Radiation Genetics, School of Radiation Medicine and Protection, Soochow University School of Medicine, Suzhou 215123, China.
² Department of Emergency, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215000, China.
³ Department of Radiation Genetics, School of Radiation Medicine and Protection, Soochow University School of Medicine, Suzhou 215123, China.
⁴ Department of Radiation Oncology, The Affiliated Hospital of Jiangnan University, Wuxi 214062, China.
⁵ Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.

Abstract

Tanshinone IIA sodium sulfonate (TSS) is a water-soluble derivative of tanshinone IIA, which is the main pharmacologically active component of Salvia miltiorrhiza. This study aimed to verify the preventive and therapeutic effects of TSS and its combined therapeutic effects with magnesium isoglycyrrhizinate (MI) in D-galactosamine- (D-Gal-) induced acute liver injury (ALI) in mice. The potential regulatory mechanisms of TSS on ALI were also examined. Our results may provide a basis for the development of novel therapeutics for ALI.