Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor

A V Stepanov; A S Rybinets; M A Dronina; S M Deev

doi:10.1007/s10517-016-3348-8

Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor

Bull Exp Biol Med. 2016 May;161(1):72-4. doi: 10.1007/s10517-016-3348-8. Epub 2016 Jun 6.

Authors

A V Stepanov¹, A S Rybinets², M A Dronina², S M Deev²

Affiliations

¹ M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia. Stepanov.Aleksei.v@gmail.com.
² M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

PMID: 27270939
DOI: 10.1007/s10517-016-3348-8

Abstract

Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.

Keywords: IL-6 receptor; chimeric receptor; fibronectin type III-like domains; gp130; gp130 dimerization.

MeSH terms

Cytokine Receptor gp130 / chemistry
Cytokine Receptor gp130 / metabolism*
Fibronectins / chemistry
Fibronectins / pharmacology*
HEK293 Cells
Humans
Protein Multimerization / drug effects
STAT3 Transcription Factor / metabolism
Signal Transduction / drug effects

Substances

Fibronectins
STAT3 Transcription Factor
Cytokine Receptor gp130