Abstract
A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.
Keywords:
Curcuminoid pyrazoles; Cytotoxicity; Gene downregulation; Telomerase.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
MeSH terms
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Cell Line, Tumor
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Cells, Cultured
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Curcumin / analogs & derivatives*
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Curcumin / chemical synthesis
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Curcumin / pharmacology*
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Down-Regulation / drug effects
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Gene Expression Regulation, Neoplastic / drug effects*
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Gene Expression Regulation, Neoplastic / genetics*
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Humans
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Proto-Oncogene Proteins c-myc / biosynthesis
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Proto-Oncogene Proteins c-myc / genetics
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Pyrazoles / chemical synthesis
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Pyrazoles / chemistry*
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Pyrazoles / pharmacology*
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Telomerase / biosynthesis
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Telomerase / genetics*
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Telomerase / metabolism
Substances
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MYC protein, human
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Proto-Oncogene Proteins c-myc
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Pyrazoles
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TERT protein, human
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Telomerase
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Curcumin