Effects of Curcuminoid Pyrazoles on Cancer Cells and on the Expression of Telomerase Related Genes

Arch Pharm (Weinheim). 2016 Jul;349(7):532-8. doi: 10.1002/ardp.201600067. Epub 2016 Jun 6.

Abstract

A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.

Keywords: Curcuminoid pyrazoles; Cytotoxicity; Gene downregulation; Telomerase.

MeSH terms

  • Cell Line, Tumor
  • Cells, Cultured
  • Curcumin / analogs & derivatives*
  • Curcumin / chemical synthesis
  • Curcumin / pharmacology*
  • Down-Regulation / drug effects
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Gene Expression Regulation, Neoplastic / genetics*
  • Humans
  • Proto-Oncogene Proteins c-myc / biosynthesis
  • Proto-Oncogene Proteins c-myc / genetics
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry*
  • Pyrazoles / pharmacology*
  • Telomerase / biosynthesis
  • Telomerase / genetics*
  • Telomerase / metabolism

Substances

  • MYC protein, human
  • Proto-Oncogene Proteins c-myc
  • Pyrazoles
  • TERT protein, human
  • Telomerase
  • Curcumin