Impact of Staphylococcus aureus accessory gene regulator (agr) system on linezolid efficacy by profiling pharmacodynamics and RNAIII expression

J Antibiot (Tokyo). 2017 Jan;70(1):98-101. doi: 10.1038/ja.2016.59. Epub 2016 Jun 8.

Authors

Rachel L Soon¹, Justin R Lenhard¹, Irene Reilly¹, Tanya Brown¹, Alan Forrest¹, Brian T Tsuji^{1

2}

Affiliations

¹ Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.
² New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USA.

PMID: 27270303
DOI: 10.1038/ja.2016.59

No abstract available

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / analysis
Bacterial Proteins / physiology*
Linezolid / pharmacology*
RNA, Bacterial / genetics*
Staphylococcus aureus / genetics*
Trans-Activators / analysis
Trans-Activators / physiology*

Substances

Agr protein, Staphylococcus aureus
Anti-Bacterial Agents
Bacterial Proteins
RNA, Bacterial
RNAIII, Staphylococcus aureus
Trans-Activators
Linezolid