P300 amplitude alterations during inhibitory control in persons with Mild Cognitive Impairment

Rocío A López Zunini; Frank Knoefel; Courtney Lord; Michael Breau; Lisa Sweet; Rafik Goubran; Vanessa Taler

doi:10.1016/j.brainres.2016.06.005

P300 amplitude alterations during inhibitory control in persons with Mild Cognitive Impairment

Brain Res. 2016 Sep 1:1646:241-248. doi: 10.1016/j.brainres.2016.06.005. Epub 2016 Jun 4.

Authors

Rocío A López Zunini¹, Frank Knoefel², Courtney Lord³, Michael Breau⁴, Lisa Sweet⁵, Rafik Goubran⁶, Vanessa Taler⁷

Affiliations

¹ University of Ottawa, School of Psychology, Vanier Hall, 136 Jean Jacques Lussier, Ottawa, ON, Canada, K1N 6N5; Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8.
² Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8; Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8; Carleton University, Faculty of Engineering and Design, 3010 The Minto Centre, 1125 Colonel By Drive, Ottawa, ON, Canada, K1S 5B6; University of Ottawa, Faculty of Medicine, 451 Smyth Road, Ottawa, ON, Canada, K1H 8M5.
³ Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8.
⁴ Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8.
⁵ Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8; Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8.
⁶ Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8; Bruyère Memory Program, Bruyère Continuing Care, 43 Bruyère St, Ottawa, ON, Canada, K1N 5C8; Carleton University, Faculty of Engineering and Design, 3010 The Minto Centre, 1125 Colonel By Drive, Ottawa, ON, Canada, K1S 5B6.
⁷ University of Ottawa, School of Psychology, Vanier Hall, 136 Jean Jacques Lussier, Ottawa, ON, Canada, K1N 6N5; Bruyère Research Institute, 75 Bruyère St., Ottawa, Ontario, Canada, K1N 5C8. Electronic address: vtaler@uottawa.ca.

PMID: 27270233
DOI: 10.1016/j.brainres.2016.06.005

Abstract

Deficits in executive function are highly noticeable in Alzheimer's disease, and recent behavioral studies have shown that such deficits - particularly during inhibitory control - can also be found in persons with Mild Cognitive Impairment (MCI). Thus, the objective of this study was to investigate behavioral and electrophysiological correlates of inhibitory control in persons with MCI. A group of persons with MCI and a group healthy older adults performed a Go/NoGo task while electroencephalogram was recorded. Our results revealed that persons with MCI performed less accurately than healthy controls during the Go and NoGo conditions. In addition, we found reduced P300 amplitudes during Go and NoGo conditions relative to healthy older adults. Our results suggest that neurocognitive mechanisms associated with target detection and evaluation (Go P300) and response inhibition (NoGo P300) are compromised in persons with MCI.

Keywords: Executive function; Go/nogo; Mild cognitive impairment; P300; Response inhibition.

MeSH terms

Aged
Cerebral Cortex / physiopathology*
Cognitive Dysfunction / physiopathology*
Electroencephalography
Event-Related Potentials, P300*
Executive Function / physiology*
Female
Humans
Inhibition, Psychological*
Male
Neuropsychological Tests