Association of the miR-146a rs2910164 polymorphism with gastric cancer susceptibility and prognosis

Future Oncol. 2016 Oct;12(19):2215-26. doi: 10.2217/fon-2016-0224. Epub 2016 Jun 8.

Abstract

Aim: Single nucleotide polymorphisms in miRNA-coding region may be involved in the development or progression of gastric cancer (GC).

Materials & methods: Six SNPs (miR-146a rs2910164, miR-196a2 rs11614913, miR-27a rs895819, miR-423 rs6505162, miR-608 rs4919510, miR-149 rs2292832) were genotyped in 898 histologically confirmed GC cases and 992 controls in this hospital-based case-control study.

Results: The G/G genotype of rs2910164 was associated with reduced risk of GC (odds ratio: 0.76, 95% CI: 0.60-0.97; p = 0.024). Meanwhile, in 838 GC cases receiving radical tumorectomy, cases bearing the G/G genotype of rs2910164 had shorter survival time comparing to cases with C/C or C/G genotype (hazard ratio: 1.36, 95% CI: 1.04-1.78, p = 0.023).

Conclusion: rs2910164 of miR-146a is associated with GC.

Keywords: gastric cancer; miRNA; overall survival; polymorphism; susceptibility.

MeSH terms

  • Adult
  • Aged
  • Alleles*
  • Female
  • Follow-Up Studies
  • Genetic Association Studies*
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Male
  • MicroRNAs / genetics*
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Neovascularization, Pathologic
  • Polymorphism, Single Nucleotide*
  • Prognosis
  • Stomach Neoplasms / diagnosis
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / mortality*
  • Stomach Neoplasms / therapy

Substances

  • MIRN146 microRNA, human
  • MicroRNAs