Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity

D A Sakharov; P G Rudakovskaya; D V Maltseva; E V Trushkin; S A Tonevitskaya

doi:10.1007/s10517-016-3359-5

Modeling of Magnetite Nanoparticles Behavior under Conditions of Microcirculation and Analysis of In Vivo Toxicity

Bull Exp Biol Med. 2016 May;161(1):116-9. doi: 10.1007/s10517-016-3359-5. Epub 2016 Jun 6.

Authors

D A Sakharov^{1

2}, P G Rudakovskaya³, D V Maltseva⁴, E V Trushkin⁴, S A Tonevitskaya⁵

Affiliations

¹ BioClinicum Research and Development Center, Moscow, Russia. d.sakharov@bioclinicum.com.
² Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia. d.sakharov@bioclinicum.com.
³ National University of Science and Technology (MISiS), Moscow, Russia.
⁴ BioClinicum Research and Development Center, Moscow, Russia.
⁵ Moscow State University of Mechanical Engineering (MAMI), Moscow, Russia.

PMID: 27265127
DOI: 10.1007/s10517-016-3359-5

Abstract

The behavior of magnetite nanoparticles was studied in the cell chip microcapillaries. No aggregation of magnetite nanoparticles under conditions of long-term circulation was noted. Biodistribution and toxicity of magnetite nanoparticles (14 nm) and aminated magnetite after their intragastric administration to mice were studied in vivo. According to mass spectrometry and microscopy data, accumulation of nanoparticles occurred mainly in the liver cells.

Keywords: in vivo toxicity; magnetite nanoparticles; microcapillary; simulation.

MeSH terms

Animals
Animals, Outbred Strains
Drug Evaluation, Preclinical
Drug Stability
Liver / drug effects
Liver / metabolism
Liver / pathology
Magnetite Nanoparticles / chemistry*
Magnetite Nanoparticles / toxicity
Male
Mice
Microcirculation
Microfluidic Analytical Techniques
Models, Biological
Solutions
Tissue Distribution

Substances

Magnetite Nanoparticles
Solutions