Intrahepatic cholestasis of pregnancy: Recent advances

Caroline Ovadia; Catherine Williamson

doi:10.1016/j.clindermatol.2016.02.004

Intrahepatic cholestasis of pregnancy: Recent advances

Clin Dermatol. 2016 May-Jun;34(3):327-34. doi: 10.1016/j.clindermatol.2016.02.004. Epub 2016 Feb 10.

Authors

Caroline Ovadia¹, Catherine Williamson²

Affiliations

¹ Women's Health Academic Centre, King's College London, London, United Kingdom.
² Women's Health Academic Centre, King's College London, London, United Kingdom. Electronic address: catherine.williamson@kcl.ac.uk.

PMID: 27265070
DOI: 10.1016/j.clindermatol.2016.02.004

Abstract

Intrahepatic cholestasis of pregnancy, also known as obstetric cholestasis, is a pruritic condition of pregnancy characterized by an underlying elevation in circulating bile acids and liver derangement, and associated with adverse fetal outcomes, such as preterm labor and stillbirth. Limited understanding of the underlying pathophysiology and mechanisms involved in adverse outcomes has previously restricted treatment options and pregnancy management. Recent advances in these research fields provide tantalizing targets to improve the care of pregnant women affected by this condition.

Publication types

Review

MeSH terms

Animals
Cholestasis, Intrahepatic / complications
Cholestasis, Intrahepatic / drug therapy*
Cholestasis, Intrahepatic / etiology*
Diabetes, Gestational / etiology
Female
Humans
Pregnancy
Pregnancy Complications / drug therapy*
Pregnancy Complications / etiology*
Pruritus / etiology*

Supplementary concepts

Intrahepatic Cholestasis of Pregnancy