Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

Dalton Trans. 2016 Aug 9;45(32):12627-31. doi: 10.1039/c6dt01979j.

Abstract

Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.

MeSH terms

  • Alzheimer Disease*
  • Amyloid beta-Peptides*
  • Antioxidants*
  • Ascorbic Acid*
  • Coordination Complexes*
  • Copper*
  • Coumarins
  • Oxidative Stress*
  • Reactive Oxygen Species

Substances

  • Amyloid beta-Peptides
  • Antioxidants
  • Coordination Complexes
  • Coumarins
  • Reactive Oxygen Species
  • Copper
  • Ascorbic Acid
  • coumarin-3-carboxylic acid