In vitro models for assessing therapeutic angiogenesis

Clara Sanz-Nogués; Timothy O'Brien

doi:10.1016/j.drudis.2016.05.016

In vitro models for assessing therapeutic angiogenesis

Drug Discov Today. 2016 Sep;21(9):1495-1503. doi: 10.1016/j.drudis.2016.05.016. Epub 2016 Jun 1.

Authors

Clara Sanz-Nogués¹, Timothy O'Brien²

Affiliations

¹ Regenerative Medicine Institute (REMEDI), Biomedical Sciences Building, National University of Ireland Galway, Newcastle Road, Galway, Ireland.
² Regenerative Medicine Institute (REMEDI), Biomedical Sciences Building, National University of Ireland Galway, Newcastle Road, Galway, Ireland. Electronic address: timothy.obrien@nuigalway.ie.

PMID: 27262402
DOI: 10.1016/j.drudis.2016.05.016

Abstract

Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of accessory vasculature to increase local tissue perfusion and to salvage tissue. However, this adaptive mechanism of repair is suboptimal in some patients. Therapeutic angiogenesis aims to stimulate new blood vessel formation via the local administration of proangiogenic agents or cell therapy products (CTPs). In this review, we provide a summary of the current understanding of in vitro models for assessing the angiogenic potential of a product.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell- and Tissue-Based Therapy
Humans
Models, Biological*
Neovascularization, Physiologic*
Vascular Diseases / drug therapy
Vascular Diseases / therapy*