1 Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, and Department of Neurology, Boston Children's Hospital, Boston, MA, and Departments of Anaesthesia and Neurology, Harvard Medical School, Boston, MA; Division of Critical Care Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA, and Departments of Anaesthesia and Pediatrics, Harvard Medical School, Boston, MA.