DNA Replication-A Matter of Fidelity

Rais A Ganai; Erik Johansson

doi:10.1016/j.molcel.2016.05.003

DNA Replication-A Matter of Fidelity

Mol Cell. 2016 Jun 2;62(5):745-55. doi: 10.1016/j.molcel.2016.05.003.

Authors

Rais A Ganai¹, Erik Johansson²

Affiliations

¹ Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden; Howard Hughes Medical Institute, Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, NY 10016, USA.
² Department of Medical Biochemistry and Biophysics, Umeå University, SE 901 87 Umeå, Sweden. Electronic address: erik.tm.johansson@umu.se.

PMID: 27259205
DOI: 10.1016/j.molcel.2016.05.003

Abstract

The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Nucleus / enzymology*
Cell Nucleus / pathology
Cell Transformation, Neoplastic / genetics
Cell Transformation, Neoplastic / metabolism
Cell Transformation, Neoplastic / pathology
DNA / biosynthesis*
DNA / chemistry
DNA / genetics
DNA Damage
DNA Mismatch Repair
DNA Repair Enzymes / metabolism
DNA Replication*
DNA-Directed DNA Polymerase / chemistry
DNA-Directed DNA Polymerase / genetics
DNA-Directed DNA Polymerase / metabolism*
Genomic Instability
Humans
Models, Molecular
Neoplasms / enzymology
Neoplasms / genetics
Neoplasms / pathology
Nucleic Acid Conformation
Protein Conformation
Structure-Activity Relationship

Substances

DNA
DNA-Directed DNA Polymerase
DNA Repair Enzymes