A Pro-metastatic tRNA Pathway

Canan Kuscu; Anindya Dutta

doi:10.1016/j.cell.2016.05.066

A Pro-metastatic tRNA Pathway

Cell. 2016 Jun 2;165(6):1314-1315. doi: 10.1016/j.cell.2016.05.066.

Authors

Canan Kuscu¹, Anindya Dutta²

Affiliations

¹ Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
² Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA. Electronic address: ad8q@virginia.edu.

PMID: 27259143
DOI: 10.1016/j.cell.2016.05.066

Abstract

tRNAs are best known as basic modules for global regulation of protein synthesis. Goodarzi et al. now show that two tRNAs upregulated in metastatic breast cancer cells enhance stability and translation of transcripts enriched with these codons, leading to specific increase in production of pro-metastatic proteins.

Publication types

Comment

MeSH terms

Codon*
Humans
Protein Biosynthesis
RNA, Transfer / genetics*

Substances

Codon
RNA, Transfer

Grants and funding

R01 AR067712/AR/NIAMS NIH HHS/United States