Abstract
A series of modular and rich electronic tridentate ferrocene aminophosphoxazoline ligands (f-amphox) have been successfully developed and used in iridium-catalytic asymmetric hydrogenation of simple ketones to afford corresponding enantiomerically enriched alcohols under mild conditions with superb activities and excellent enantioselectivities (up to 1 000 000 TON, almost all products up to >99% ee, full conversion). The resulting chiral alcohols and their derivatives are important intermediates in pharmaceuticals.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohols / chemical synthesis*
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Alcohols / chemistry
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Catalysis
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Ferrous Compounds / chemical synthesis*
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Ferrous Compounds / chemistry
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Hydrogenation
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Iridium / chemistry*
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Ketones / chemistry*
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Ligands
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Metallocenes / chemical synthesis*
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Metallocenes / chemistry
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Models, Molecular
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Oxazoles / chemical synthesis*
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Oxazoles / chemistry
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Stereoisomerism
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Thermodynamics
Substances
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Alcohols
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Ferrous Compounds
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Ketones
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Ligands
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Metallocenes
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Oxazoles
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Iridium
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ferrocene