LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia

Leukemia. 2016 Sep;30(9):1959-62. doi: 10.1038/leu.2016.116. Epub 2016 May 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Animals
  • Genetic Therapy / adverse effects*
  • Interleukin Receptor Common gamma Subunit / genetics*
  • LIM Domain Proteins / genetics*
  • Leukemia, T-Cell / genetics*
  • Mice
  • Mice, Transgenic
  • Thymocytes / pathology
  • X-Linked Combined Immunodeficiency Diseases*

Substances

  • Adaptor Proteins, Signal Transducing
  • Il2rg protein, mouse
  • Interleukin Receptor Common gamma Subunit
  • LIM Domain Proteins
  • Lmo2 protein, mouse