Abstract
Over recent years, D-peptides have attracted increasing attention. D-peptides increase enzymatic stability, prolong the plasma half-life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L-peptide. Therefore, D-peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D-peptides with biological activity.
Keywords:
mirror-image phage display; molecular recognition; peptides; retro-inverso.
© 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / drug therapy
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Animals
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Antineoplastic Agents / therapeutic use
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Blood-Brain Barrier / metabolism
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Cell Line, Tumor
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Drug Design
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HIV Fusion Inhibitors / pharmacology
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Humans
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Low Density Lipoprotein Receptor-Related Protein-1 / metabolism
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Neuropilin-1 / metabolism
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Peptides / chemistry*
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Peptides / pharmacology
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Peptides / therapeutic use
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Receptors, Nicotinic / metabolism
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Receptors, Transferrin / metabolism
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Stereoisomerism
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Vaccines, Subunit
Substances
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Antineoplastic Agents
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HIV Fusion Inhibitors
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Low Density Lipoprotein Receptor-Related Protein-1
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Peptides
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Receptors, Nicotinic
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Receptors, Transferrin
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Vaccines, Subunit
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Neuropilin-1