D-Peptides as Recognition Molecules and Therapeutic Agents

Chem Rec. 2016 Aug;16(4):1772-86. doi: 10.1002/tcr.201600005. Epub 2016 Jun 3.

Abstract

Over recent years, D-peptides have attracted increasing attention. D-peptides increase enzymatic stability, prolong the plasma half-life, improve oral bioavailability, and enhance binding activity and specificity with receptor or target proteins, in comparison with the corresponding L-peptide. Therefore, D-peptides are considered to have potential as recognition molecules and therapeutic agents. This review focuses on the design and application of D-peptides with biological activity.

Keywords: mirror-image phage display; molecular recognition; peptides; retro-inverso.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Animals
  • Antineoplastic Agents / therapeutic use
  • Blood-Brain Barrier / metabolism
  • Cell Line, Tumor
  • Drug Design
  • HIV Fusion Inhibitors / pharmacology
  • Humans
  • Low Density Lipoprotein Receptor-Related Protein-1 / metabolism
  • Neuropilin-1 / metabolism
  • Peptides / chemistry*
  • Peptides / pharmacology
  • Peptides / therapeutic use
  • Receptors, Nicotinic / metabolism
  • Receptors, Transferrin / metabolism
  • Stereoisomerism
  • Vaccines, Subunit

Substances

  • Antineoplastic Agents
  • HIV Fusion Inhibitors
  • Low Density Lipoprotein Receptor-Related Protein-1
  • Peptides
  • Receptors, Nicotinic
  • Receptors, Transferrin
  • Vaccines, Subunit
  • Neuropilin-1