Engineering Paper-Based Sensors for Zika Virus

Robert J Meagher; Oscar A Negrete; Koen K Van Rompay

doi:10.1016/j.molmed.2016.05.009

Engineering Paper-Based Sensors for Zika Virus

Trends Mol Med. 2016 Jul;22(7):529-530. doi: 10.1016/j.molmed.2016.05.009. Epub 2016 May 30.

Authors

Robert J Meagher¹, Oscar A Negrete², Koen K Van Rompay³

Affiliations

¹ Sandia National Laboratories, Biotechnology and Bioengineering Department, Livermore, CA 94551, USA. Electronic address: rmeaghe@sandia.gov.
² Sandia National Laboratories, Biotechnology and Bioengineering Department, Livermore, CA 94551, USA.
³ California National Primate Research Center, University of California, Davis, CA 95616, USA.

PMID: 27255410
DOI: 10.1016/j.molmed.2016.05.009

Abstract

The emergence of Zika virus (ZIKV) infections in Latin America and Southeast Asia has created an urgent need for new, simple, yet sensitive, diagnostic tests. We highlight recent work using paper-based sensors coupled with CRISPR/Cas9 to detect ZIKV RNA as a new approach to achieve rapid development and deployment of field-ready diagnostics for emerging infectious diseases.

Keywords: CRISPR/Cas9; emerging infectious diseases; molecular diagnostics; paper microfluidics; toehold sensors.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

CRISPR-Cas Systems*
Humans
Microfluidic Analytical Techniques / methods*
Paper
RNA, Viral / genetics*
RNA, Viral / isolation & purification
Zika Virus / genetics*
Zika Virus / isolation & purification*
Zika Virus Infection / diagnosis*

Substances

RNA, Viral