Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV

Pediatr Infect Dis J. 2016 Oct;35(10):1137-9. doi: 10.1097/INF.0000000000001253.

Abstract

Background: Vaccine schedules including bivalent oral and inactivated poliovirus vaccines will replace trivalent oral poliovirus vaccines in 2016.

Methods: We evaluated rotavirus immunoglobulin A seroresponses when the second dose of Rotarix at 16 weeks was given concomitantly with inactivated or bivalent oral poliovirus vaccines.

Results: Rotavirus immunoglobulin A seroresponse rate at week 28 was 15% lower in recipients of bivalent oral poliovirus vaccines compared with inactivated poliovirus vaccines.

Conclusion: Bivalent oral poliovirus vaccine decreases rotavirus IgA seroresponse rates when coadministered at 16 weeks of age.

Publication types

  • Clinical Trial, Phase IV
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood*
  • Humans
  • Immunoglobulin A / blood*
  • Infant
  • Poliovirus Vaccines / immunology*
  • Rotavirus / immunology
  • Rotavirus Infections / epidemiology
  • Rotavirus Infections / immunology*
  • Rotavirus Infections / prevention & control*
  • Rotavirus Vaccines / immunology*
  • Seroepidemiologic Studies

Substances

  • Antibodies, Viral
  • Immunoglobulin A
  • Poliovirus Vaccines
  • Rotavirus Vaccines