Oxygen Nanocarrier for Combined Cancer Therapy: Oxygen-Boosted ATP-Responsive Chemotherapy with Amplified ROS Lethality

Adv Healthc Mater. 2016 Sep;5(17):2161-7. doi: 10.1002/adhm.201600121. Epub 2016 Jun 2.

Abstract

Oxygen nanocarrier (A/D-ONC) with a polymeric core entrapping hemoglobin and a cationic lipid shell absorbing a DOX-intercalating DNA duplex is developed. After endocytosis oxygenated A/D-ONC donates O2 to cancer cells that acts therapeutically by: (1) increasing intracellular ATP content that promotes DOX release, thereby converting ATP to the trigger of detrimental chemotherapy; (2) by synchronously increasing the ROS amount to amplify the lethality to cancer cells.

Keywords: aptamers; cancer therapy; chemotherapy; mitochondria; oxygen nanocarrier.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Cell Line, Tumor
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Drug Carriers* / chemistry
  • Drug Carriers* / pharmacology
  • Hemoglobins* / chemistry
  • Hemoglobins* / pharmacology
  • Humans
  • Nanoparticles* / chemistry
  • Nanoparticles* / therapeutic use
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Oxygen* / chemistry
  • Oxygen* / pharmacology
  • Reactive Oxygen Species / metabolism

Substances

  • Drug Carriers
  • Hemoglobins
  • Reactive Oxygen Species
  • Doxorubicin
  • Adenosine Triphosphate
  • Oxygen