Solid-Phase Synthetic Strategies for the Preparation of Purine Derivatives

Soňa Krajčovičová; Miroslav Soural

doi:10.1021/acscombsci.6b00061

Solid-Phase Synthetic Strategies for the Preparation of Purine Derivatives

ACS Comb Sci. 2016 Jul 11;18(7):371-86. doi: 10.1021/acscombsci.6b00061. Epub 2016 Jun 10.

Authors

Soňa Krajčovičová¹, Miroslav Soural^{1

2}

Affiliations

¹ Department of Organic Chemistry, Faculty of Science, Palacký University , 771 46 Olomouc, Czech Republic.
² Institute of Molecular and Translation Medicine, Faculty of Medicine and Dentistry, Palacký University , Hněvotínská 5, 779 00, Olomouc, Czech Republic.

PMID: 27248804
DOI: 10.1021/acscombsci.6b00061

Abstract

This Review summarizes all of the currently described strategies applicable for the solid-phase synthesis of purine derivatives. The individual approaches are classified according to the immobilization procedure used resulting in a linkage of the final scaffold at various positions.

Keywords: combinatorial chemistry; immobilization; purine; solid-phase synthesis; xanthine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Combinatorial Chemistry Techniques / methods*
Indicators and Reagents
Purines / chemical synthesis*
Solid-Phase Synthesis Techniques / methods*

Substances

Indicators and Reagents
Purines