Manganese(III) Acetate-Promoted Cross-Coupling Reaction of Benzothiazole/Thiazole Derivatives with Organophosphorus Compounds under Ball-Milling Conditions

Liang Li; Jun-Jie Wang; Guan-Wu Wang

doi:10.1021/acs.joc.6b00786

Manganese(III) Acetate-Promoted Cross-Coupling Reaction of Benzothiazole/Thiazole Derivatives with Organophosphorus Compounds under Ball-Milling Conditions

J Org Chem. 2016 Jul 1;81(13):5433-9. doi: 10.1021/acs.joc.6b00786. Epub 2016 Jun 10.

Authors

Liang Li¹, Jun-Jie Wang¹, Guan-Wu Wang¹

Affiliation

¹ CAS Key Laboratory of Soft Matter Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Hefei National Laboratory for Physical Sciences at Microscale, and Department of Chemistry, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.

PMID: 27248000
DOI: 10.1021/acs.joc.6b00786

Abstract

The first solvent-free manganese(III) acetate-promoted reaction of benzothiazole/thiazole derivatives with organophosphorus compounds including phosphine oxides, phosphinate ester, and phosphonate diester has been efficiently developed under ball-milling conditions, providing a highly efficient and green protocol to structurally diverse C2-phosphonylated benzothiazole/thiazole derivatives with remarkable functional group tolerance and excellent yields.

Publication types

Research Support, Non-U.S. Gov't