An epidermoid inclusion cyst is basically an epidermoid cyst resulting from the traumatic implantation of epidermal elements into the dermis with their subsequent cystic transformation. A case of an epidermal inclusion cyst of the cheek region is described in a 54-year-old man, whose feature was rather unusual, in that it presented as a fixed, indurated, inflamed, and sometimes, mimicking a parotid gland infection. The cyst was particularly persistent and recurred within a month of its medical treatment and had to be re-excised along with the adjacent parotid mass.